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The North American, Central American, and South American cigarettes comprised various plant wrappers, and upon their return to Spain, maize wrappers were introduced, with fine paper wrappers coming in the 17 century

Adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were calculated and reported for independent variables

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However, by the 19th century, amidst the Industrial Revolutions innovative splurge, the concept of tobacco consumption began to shift towards a more portable and accessible form, paving the path for the inception of the cigarette